At LRI, our Research & Development (R&D) division is dedicated to advancing regenerative medicine and longevity science. Through cutting-edge research, we aim to develop innovative treatments and therapies that push the boundaries of healthcare, ensuring better outcomes.
Gene Therapy Using Hybrid CRISPR/Cas9 System
Current methods like viral vectors have risks such as cytotoxicity and off-target effects. Investigating exosomes (small vesicles) as safer carriers capable of penetrating biological barriers, including the blood-brain barrier. Enhancing exosomes to carry larger molecules, like Cas9 plasmids, by creating hybrid exosomes with liposomes. Could revolutionize gene manipulation in human cells by improving the delivery of CRISPR/Cas9. Develop a stable, scalable delivery system for treating rare and genetically inherited diseases.
Exosome Infused Filler: The Future of Aesthetic Fillers
Exo-Filler is a groundbreaking project aimed at overcoming the limitations of traditional fillers used in aesthetic medicine and dermatology. By purifying biological materials derived from plasma, we produce biocompatible fillers with tailored firmness levels.
The Role of Bioelectricity in Modulating Cellular Senescence and Promoting Regeneration
Our ongoing project explores the role of bioelectricity in modulating cellular senescence and promoting regeneration. Cellular senescence, a natural process where cells cease to divide and exhibit age-related changes, contributes to tissue dysfunction, inflammation, and the progression of age-related diseases. Senescent cells accumulate over time and secrete pro-inflammatory molecules, known as the senescence-associated secretory phenotype (SASP).We are investigating how bioelectric signals, the natural electrical impulses generated by cells, can influence cellular behavior, tissue homeostasis, and regeneration. Our hypothesis is that targeted bioelectric stimulation can alter the pathways of cellular senescence, reduce SASP factors, and enhance regenerative processes.