Edited by Steven R. Cohen, MD; Tunc Tiryaki, MD; Patrick L. Tonnard, MD, PhD; Alexis M. Verpaele, MD, PhD The rapidly rising use of the promising techniques in facial surgery requires knowledge of how facial anatomy changes during the ageing process,

Enzymatic digestion of extracellular matrix (ECM) from lipoaspirate is the conventional form of harvesting stromal vascular fraction (SVF) called enzymatically digested SVF (E-SVF). Mechanical SVF (M-SVF) isolation has emerged as an alternative meth

Dr Cohen is a plastic surgeon in private practice in San Diego, CA. Ms Wesson is an undergraduate student, University of California, Los Angeles, CA.

The use of stromal vascular fraction (SVF) cells in both basic research and clinical trial has significantly increased during the last decade due to a variety of newly suggested therapeutic indications

Dr Cohen is a Clinical Professor of Plastic Surgery, University of California, San Diego; and is a plasticsurgeon in private practice in La Jolla, CA.

The author is to be congratulated on addressing an emerging practice for skin regeneration employing topically applied nanofat plus a compounded liposomal delivery

Autologous adipose-derived stromal vascular fraction (SVF) is a reliable source for regenerative surgery,1 with diverse applications such as bone regeneration, dentistry, hair growth, chronic wounds, and chronic bowel disease among others.2

Recent advances in understanding of facial ageing have resulted in significant insights into facial soft tissue and bony volume loss. Lambros1 documented photometric changes that showed that soft tissue of the face deflates with ageing.

Nanofat was introduced by Tonnard and Verpaele in 2013. Their initial observations in intradermal applications showed improvementin the appearance of the skin.