The Truth About Anti-Ageing Supplements: The Science, Hype and Smart Choices

The Rise of Anti-Ageing Supplements

The pursuit of youth and longevity has fuelled a booming anti-ageing industry, with consumers spending billions on anti-ageing supplements, skincare and professional treatments. From collagen drinks to NAD boosters, health patches, wellness gummies and antioxidants, the market is flooded with products promising to combat wrinkles, boost energy and slow the ageing process. But how much of this is backed by science and how much is marketing hype?

Breaking Down Popular Anti-Ageing Supplements
1. Collagen: The Skin and Joint Booster
The Science

Collagen is the body’s most abundant protein, providing structural support for skin, joints and connective tissues. It maintains elasticity and strength, keeping skin firm and joints flexible. However, from the mid-20s, natural collagen production declines by around 1% per year, contributing to wrinkles, sagging skin and reduced joint function.

Collagen supplements, often hydrolysed into smaller peptides for better absorption, are thought to help counteract this decline. Studies suggest oral supplementation may improve skin hydration, elasticity and overall appearance. A 2019 systematic review in Nutrients found consistent collagen intake led to significant improvements in skin elasticity and moisture levels.

Collagen and Joint Health

Collagen is a key component of cartilage, the tissue that cushions joints and enables smooth movement. As collagen levels fall, cartilage weakens, increasing the risk of joint discomfort, stiffness and osteoarthritis.

Collagen and Joint HealthPotential benefits of supplementation include:

• Joint pain relief- some research has indicated that collagen peptides may help alleviate joint pain, particularly in osteoarthritis or physically active individuals.
• Cartilage repair- Collagen provides essential amino acids like glycine and proline, which contribute to cartilage regeneration.
• Improved flexibility and mobility- Regular supplementation may support joint function by maintaining cartilage integrity and reducing inflammation.
• Slower degeneration- Some studies suggest collagen supplementation could help slow the progression of degenerative joint conditions by stimulating the body’s natural collagen production.

While research is promising, effectiveness varies depending on individual metabolism, dosage and collagen type. A balanced diet and active lifestyle may enhance joint health further.

Potential Benefits of Collagen:

• Skin Health- May improve hydration, elasticity and smoothness, reducing fine lines and wrinkles.
• Joint Support- May help maintain cartilage integrity, potentially easing joint pain and stiffness.
• Hair and Nail Strength- Some evidence suggests collagen may enhance hair and nail resilience.
• Gut Health- Collagen contains amino acids like glycine, which may support digestive health by strengthening the gut lining.

Limitations & Risks

• Individual Variability: Effectiveness depends on metabolism, absorption and overall diet.
• Cofactor Deficiencies: Collagen synthesis requires vitamin C, zinc and hyaluronic acid. Without these, the body may struggle to utilise supplements.
• Quality Concerns: Many supplements lack clinical testing, and some may contain additives or contaminants. Choosing third-party-tested, high-quality formulations is crucial. Consult with a medical practitioner for advice and guidance when choosing supplements.

Maximising Effectiveness:
2. NAD Boosters: The Cellular Energy Enhancers
The Science

Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme found in every living cell, playing a critical role in energy metabolism, DNA repair and overall cellular health. It acts as a key player in mitochondrial function, facilitating the conversion of nutrients into energy and supporting cellular repair mechanisms.

However, as we age, NAD+ levels decline significantly; by middle age, levels can drop by nearly 50%, and this decline has been linked to age-related conditions including metabolic disorders, neurodegenerative diseases, and reduced muscle function.

Supplements such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are precursors to NAD+, meaning they help replenish NAD+ levels in the body. By restoring these levels, researchers believe they may help improve mitochondrial efficiency, support cognitive function, enhance skin health and potentially slow some aspects of ageing.

Potential Benefits:

Research into NAD+ supplementation is still in its early stages, but emerging studies suggest several promising benefits:
• Cellular Repair & Longevity: Supports DNA repair by activating sirtuins, proteins linked to ageing and cellular defence.
• Energy & Metabolism Boost: Enhances mitochondrial function, potentially improving energy levels, endurance, and metabolic efficiency.
• Cognitive Support: May protect neurons, improve brain function and reduce cognitive decline associated with ageing.
• Skin & Tissue Health: May aid in skin cell repair, reducing signs of ageing and improving overall skin resilience.
• Potential Cardiovascular Benefits: Some studies suggest NAD+ precursors might support heart health by improving vascular function and reducing inflammation.

Limitations & Risks:

While NAD boosters are gaining popularity, there are still limitations and uncertainties to consider:
• Limited Long-Term Human Studies: Most research has been conducted on animals, with human studies still in early phases. The long-term effects of NAD+ supplementation remain unclear.
• Varied Absorption & Effectiveness: Not all NAD+ precursors have equal bioavailability, and some may not raise NAD+ levels as efficiently in all individuals.
• Cost & Accessibility: High-quality NAD+ precursors can be expensive and regulatory oversight on supplement purity varies.

The Verdict:

NAD boosters hold exciting potential for enhancing cellular energy, cognitive function and longevity, but more research is needed to confirm their long-term efficacy and safety. If considering supplementation, it’s best to consult a healthcare professional to determine if NAD+ precursors align with your health goals.

Contact our experts at the London Regenerative Institute.

3. Antioxidants: The Defence Against Oxidative Stress
The Science

Oxidative stress occurs when the body accumulates an excess of free radicals- unstable molecules that can damage cells, proteins and DNA. This process plays a significant role in ageing, inflammation and various chronic diseases, including cardiovascular disease, neurodegeneration and cancer.

Antioxidants help counteract oxidative stress by neutralising free radicals, therefore protecting cells from premature damage. Our bodies naturally produce some antioxidants, but we also rely on dietary sources including vitamins, polyphenols and enzymes.

Some of the most well-researched antioxidants include:
• Vitamin C: A water-soluble antioxidant crucial for collagen synthesis, immune function and skin protection against UV radiation.
• Vitamin E: A fat-soluble antioxidant that protects cell membranes and supports skin health.
• Coenzyme Q10 (CoQ10): A key compound involved in energy production within mitochondria, CoQ10 may help reduce oxidative stress and improve heart and brain function.
• Resveratrol: Found in red wine, grapes and berries, resveratrol has shown promise in animal studies for its potential longevity and anti-inflammatory effects.
• Glutathione: Often called the “master antioxidant,” glutathione plays a central role in detoxification and cellular repair.

Potential Benefits:

Research suggests that antioxidants can offer several health benefits, including:
• Anti-Ageing & Skin Health: Supports collagen production, reduces fine lines, and protects against environmental stressors like UV rays and pollution.
• Cognitive Protection: May reduce neuroinflammation and help slow age-related cognitive decline.
• Cardiovascular Support: Certain antioxidants, like flavonoids and CoQ10, may improve circulation and reduce oxidative damage to blood vessels.
• Immune System Boost: Helps reduce inflammation and supports immune cell function.
• Metabolic & Mitochondrial Health: Some antioxidants, such as alpha-lipoic acid, may enhance insulin sensitivity and support energy metabolism.

Limitations & Risks:

Despite their potential, antioxidants are not a cure-all and their effectiveness depends on various factors:
• Varied Absorption & Bioavailability: Not all antioxidants are well absorbed when taken orally; some, like glutathione, are more effective when consumed through foods or produced naturally by the body
• Excessive Intake Risks: High doses of certain antioxidants (e.g., vitamin E and beta-carotene) may have pro-oxidant effects, potentially increasing the risk of disease rather than preventing it.
• Interactions with Medications: Some antioxidants, like resveratrol and vitamin K, may interfere with blood thinners or other medications.
• Not a Substitute for a Healthy Lifestyle: While beneficial, antioxidants work best when combined with a balanced diet, exercise and overall healthy lifestyle.

The Verdict:

Antioxidants are essential for cellular health and may help slow the ageing process, but they should be consumed as part of a nutrient-rich diet rather than in excessive supplement form. Whole foods like berries, nuts, green tea and dark leafy greens offer a broad spectrum of antioxidants with optimal absorption.

Hype vs. Science

While some anti-ageing supplements show promise, the industry is rife with bold claims and limited regulation. Doctors and longevity researchers urge consumers to prioritise evidence-based choices, as many products lack robust clinical studies.

Relying solely on supplements is not a magic bullet for ageing. Instead, they should complement a comprehensive anti-ageing strategy, including:

1. A Science-Backed Skincare Routine
• Exosomes- biotech skincare like Morphiya offer high-quality and comprehensive anti-ageing skincare strategy which stimulates collagen production and improves elasticity
• Sunscreen: The best anti-ageing product for preventing UV-induced skin damage.
• Hyaluronic Acid: Keeps skin hydrated and plump.

2. Professional Treatments for Enhanced Results
• RF Microneedling & Exosomes: Stimulate skin renewal and collagen production.
• Polynucleotides: Emerging in the field of regenerative aesthetics, helping with skin repair and hydration.

3. Lifestyle Factors That Outperform Supplements
• Balanced Nutrition: A diet rich in omega-3s, vitamins, and polyphenols supports healthy ageing.
• Exercise & Sleep: Both boost natural growth hormone production, improving skin elasticity and cognitive function.
• Stress Management: Chronic stress accelerates ageing—practices like meditation and mindfulness help slow it down.

A Balanced Approach to Anti-Ageing
Tips for Smart Supplement Choices:

• Look for clinical studies backing the product
• Choose high-quality, third-party tested supplements
• Pair supplements with proven skincare and lifestyle habits
• Consult a healthcare professional before starting any new supplement – book your consultation with the experts at the London Regenerative Institute.

The best approach to anti-ageing is holistic. Combining science-backed supplements, skincare innovations like Morphiya, professional treatments and healthy living is the best approach to enjoying a long and healthy life. Instead of chasing trends, focus on long-term, evidence-based strategies for youthful skin and overall wellbeing.

Take Control of Your Health with Longevity Screening

At the London Regenerative Institute, we believe in proactive, science-led healthcare that optimises vitality and extends healthspan. Our Longevity Screening provides a comprehensive assessment of key biomarkers, cellular health and metabolic function, identifying early signs of ageing and potential risk factors before they impact your wellbeing.

By understanding your body’s unique needs, we can develop personalised regenerative strategies to enhance energy levels, cognitive function and overall resilience. Whether you’re looking to maintain peak performance or future-proof your health, our advanced screening can help you take the right steps towards a longer, healthier life.

Invest in your future today. Contact the London Regenerative Institute to book your Longevity Screening and start your journey towards optimal health.